5631-Response to Kelly Pelegrin`s Post

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5631-Responseto Kelly Pelegrin’s Post

5631-Responseto Kelly Pelegrin’s Post

Inessence, Pelegrin concludes that RT is experiencing an allergicreaction resulting in anaphylaxis and inflammation. Additionally, sheexplains that when entering the subject’s body via the skin, thebee venom interacts with mast cells, triggering the release ofhistamine and other chemical factors such as bradykinins andleukotrienes, which cause inflammation and potentiate pain,respectively. Seemingly, Pelegrin’s interpretation of theself-defense mechanism going on in RT’s body is accurate.

Ananaphylaxis is a severe reaction that occurs when a person’s immunesystem overreacts to an allergen in the body by releasing chemicalsthat cause allergy-like symptoms essentially, the symptoms areusually localized in a single area (Simons,Ardusso, Bilò, Cardona, Ebisawa, El-Gamal, &amp Sanchez-Borges,2014).Intrinsically, anaphylactic reactions are usually triggered bycertain foods, insect bites, or medications additionally, one is ata risk of developing anaphylaxis if he/she has been previouslyexposed to the reaction. Correspondingly, anaphylaxis suffices as anexplanation of the swelling on RT’s arm additionally, it is asuitable diagnosis given that RT has experienced another bee sting inthe past.

Seemingly,Pelegrin’s analysis of RT’s inflammation and pain is also inaccordance with prevailing principles of the human body’sprotection mechanism. When an allergen first enters the human body,IgE that is complementary to the antigens on the surface of theforeign body attaches to mast cells and basophils in a process knownas sensitization (Moellman,2013).During a reentry of the same antigen, in this case, the bee’svenom, the sensitized cells remember the antigens of the allergen andtrigger degranulation. Intrinsically, this entails the secretion ofcertain chemicals, such as histamine and prostaglandins that causeinflammation around the affected area, as well inflammation (thisconstitutes the allergic reaction that was manifested in RT).

Multiplestudies have also implicated the kinin system in hypersensitivereactions effectively, it secretes bradykinins, which are mainlyinvolved in inflammation, but if in excess can potentiate pain to theaffected region (Baldo &amp Pham, 2013). Essentially, the mainpurpose of these symptoms is to make the person aware of the damageto the body so that he/she can take appropriate action. Overall,Pelegrin’s article is thorough and thoughtful.


Baldo,B. A., &amp Pham, N. H. (2013).&nbspDrugallergy: Clinical aspects, diagnosis, mechanisms, structure-activityrelationships.New York, NY: Springer.

Moellman,J. J. (2013). Anaphylaxis and Hypersensitivity Reactions.&nbspJournalof Emergency Medicine,&nbsp45(3),478.

Simons,F. E. R., Ardusso, L. R., Bilò, M. B., Cardona, V., Ebisawa, M.,El-Gamal, Y. M., … &amp Sanchez-Borges, M. (2014). Internationalconsensus on (ICON) anaphylaxis.&nbspWorldAllergy Organization Journal,&nbsp7(1),1.

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