Response to Donna Mather`s Post

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Responseto Donna Mather’s Post

5631-Response to Donna Mather’s Post

Notably,Donna Mather believes that RT has a type 1 hypersensitive reactionin such a way, she attributes the itching on his throat and tightnesswith breathing to histamine, which is a major cytokine that issecreted during such reactions. Additionally, she attributes theswelling on his arm to the degranulation that occurs upon thecrosslinking between IgE sensitized mast cells and basophils withantigens. Essentially, the fact that mast cells are located inallergen-prone regions such as the skin and respiratory tract furtherstrengthens her suspicions that RT is suffering from a type 1allergic reaction.

Besides,Donna’s deductions are seemingly correct since type 1 reactionsoccur after re-exposure to particular antigens (Kutlu et al., 2016).RT’s medical history shows that he has been stung by a beepreviously in such a way, this second sting is a re-exposure to theallergen (the sting) hence her diagnosis is correct. During theinitial exposure, IgE receptors bind the Fce receptors of the bloodbasophils and mast cells, making them sensitized. Correspondingly,upon a subsequent exposure to the same antigen results in across-linking of the IgEs that were bound to the mast cells andbasophils during sensitization this triggers degranulation, whichfurther leads to the release of pharmacologically active componentssuch as leukotriene 4, prostaglandins, and histamine(Goodman &amp Fuller, 2014).Intrinsically, this confirms that Mather’s implication of histaminein RT’s hypersensitivity is justified. Besides, histamine, whenreleased during degranulation, causes smooth muscle contraction andvasodilation in the surrounding tissues (McCance&amp Huether, 2015).&nbspThisaccounts for the swelling at the place where RT was stung by the bee.Given this theoretical foundation, Mather’s analysis of RT’ssituation seems to be informed, accurate, and extremely insightful.Additionally, it correlates to pre-existing research, which reaffirmsits credibility.


Goodman,C. C., &amp Fuller, K. S. (2014).&nbspPathology:implications for the physical therapist.Elsevier Health Sciences.

Kutlu,A., Ucar, R., Aydin, E., Arslan, S., &ampCalıskaner, A. Z. (2016).Could aluminum be a new hidden allergen in type 1 hypersensitivityreactions when used as a drug additive?&nbspAdvancesin Dermatology and Allergology,&nbsp33,243-245.

McCance,K. L., &amp Huether, S. E. (2015).&nbspPathophysiology:The biologic basis for disease in adults and children.Elsevier Health Sciences.

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